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Effects of hemipancreatectomy on insulin secretion and glucose tolerance in healthy humans
demonstrated, in addition to higher weight loss in the group treated with high-dose liraglutide 3.0 mg/day for 32 weeks, significant improvements not only of fasting glucose and HOMA-IR, but also of the post-load glucose measured by OGTT, OGTT-derived insulin sensitivity index (SIOGTT), and corrected the early insulin response to a glucose challenge (IGI/HOMA) compared to placebo [62]
Not sustainable long-term (insufficient nutrition), but acceptable as bridge through worst 48 hours of each week
However, excessively concentrated solutions may cause irritation that paradoxically reduces absorption by triggering protective mucus secretion
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Five doses of cagrilintide were examined (0.3, 0.6, 1.2, 2.4, or 4.5 mg) compared to a single dose of liraglutide (3.0 mg) or volume-matched placebo for 6 placebo groups
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