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The TRIUMPH-4 trial of retatrutide involved 445 participants with obesity and knee osteoarthritis, with 84% having a body mass index of 35 and over (the criteria for severe obesity)

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Alex compares this to growth hormone, which has a short half-life but exerts prolonged effects by boosting IGF-1, which lasts much longer

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The pathological increase in NADPH oxidase-mediated superoxide (O) and peroxide production from inflammatory phagocytic cells in the course of this inflammatory reaction acts as source of oxidative stress