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Nausea ranged from approximately 11% at the lowest 1 mg dose to 64% in some intermediate-dose arms, with about 33% reported in the 9 mg fixed-dose arm (the highest-efficacy arm)
However, oral medications are generally cheaper to manufacture than injectable biologics
Restrictions on patients with a history of cancer or bariatric surgery, as well as on those taking concomitant medications have further hampered enrollment
Published trial data show a large share of the weight lost on the drugs is lean muscle
Fundamentally, GLP-1RAs work by stimulating insulin secretion and inhibiting glucagon secretion in a glucose-dependent manner [9], which explains their associated low risk of hypoglycaemia
We do not know why dogs get lipomas
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