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The primary outcome was the incidence of major adverse limb events (defined as either one of the following events: newly diagnosed critical limb ischemia, percutaneous transluminal angioplasty or peripheral bypass of peripheral artery disease, or nontraumatic amputation)
Worth Trying or Not
Non-Steroid Creams Non-steroidal treatments deserve mention
L-carnitine supplementation can alleviate muscle cramps through different mechanisms, including restoration of muscular carnitine and enhanced mitochondrial -oxidation [9, 10]
CLA supplements that provide a free fatty acid mixture high in isomers such as cis-9, trans-11 and trans-10, cis-12 help to mobilise stored fat so that the body can more easily burn it for energy
However, the authors included only six RCTs involving tirzepatide and, as opposed to our meta-analysis, did not provide information on comparative effects across different doses of the two medications [55]
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