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The combination also increases the risk of nausea and can further stress the GI tract during the window when side effects are already most likely

Siddiqui EM, Mehan S, Bhalla S, Shandilya A (2022) Potential role of IGF-1/GLP-1 signaling activation in intracerebral hemorrhage

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One-third of adherent participants achieved at least 20% weight loss, versus under 3% with placebo

These mechanisms provide a plausible biological basis for clinical observations linking GLP-1 RAs to improved mood, motivation, and hedonic control independent of weight reduction