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Daily water intake targets The National Academies of Sciences, Engineering, and Medicine recommend 3.7 liters per day of total water intake for men and 2.7 liters per day for women

Patients should be advised to: Eat smaller, more frequent meals rather than large portions Avoid high-fat, greasy, or spicy foods that delay gastric emptying further Reduce intake of foods that commonly trigger nausea (strong odors, very sweet items) Stay well-hydrated with small sips of water throughout the day Avoid lying down immediately after eating (remain upright for 2-3 hours) Gradual dose titration is critical for improving tolerance

Shu, X.O., Zheng, Y., Cai, H., Gu, K., Chen, Z., Zheng, W

"Toxic hepatitis induced by show-wu-pian, a Chinese herbal preparation"

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Its primary alkaloids, mitragynine and 7-hydroxymitragynine, interact with the brains opioid receptors, but differently than classic opioids