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Specifically, it increases POMC and CART expression in the hypothalamus, the peptides that tell your brain you are full
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Together, these modifications produce a compound reported to be approximately 26-fold more potent than native -MSH in adenylyl cyclase assay systems, positioning MT1 as a common reference compound in MC1R pharmacology and melanogenesis pathway research
PMC 310948
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Albumin binding slows clearance and extends exposure
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