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Background Alcohol consumption is widespread globally, but the resulting hangovers can lead to discomfort, such as headaches, dizziness, and fatigue, significantly impacting daily activities like work performance and driving

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Introducing a fluorine atom at this position yielded Compound 68 , which demonstrated slightly improved inhibitory potency (IC 50 : 6.5 nM) and significantly enhanced metabolic stability (RLM t 1/2 : 105 min) (Figure 19)

The key difference is dosing range