I was still able to eat whole meals and enjoy life and food, but food had become an afterthought
A Phase 1a, blinded, placebo-controlled, randomized, single- and multiple-ascending-dose study was done to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple doses of orforglipron
This pattern is consistent with a healthy-user bias, whereby individuals who are younger and generally healthier tend to experience more favorable outcomes regardless of treatment exposure
So unsurprisingly, the weight tends to start falling off quite quickly
The influence of parathyroid hormone-related protein on hepatic IGF-1 production [PMID: 1306983] Laboratory literature summary: The influence of parathyroid hormone-related protein on hepatic IGF-1 production
From this it appeared to Holst that something had changed in their gut that altered its metabolism