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According to Innerbody's 2026 review, a 2013 in vitro study found treated cells showed statistically significant increases in melatonin biomarkers, and a 2021 human trial of 75 women found 0.5mg daily increased melatonin by 160% versus placebo
250 mcg Cognizin Citicoline
Spear JF, Prabu SK, Galati N, Raza H, Anandatheerthavarada HK, et al
It was discontinued in 2008 due to manufacturing issues (not safety concerns) and is still available through compounding pharmacies
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doi: 10.4103/0019-5413.114909
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