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The peptide upregulates VEGF expression in multiple cell types and enhances endothelial cell responses to VEGF signaling

Because U2OS cells do not express detectable procaspase-1, this result supports the idea that X(PC) can engage off-target apoptotic signaling when its intended substrate is absent

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These may include injection site discomfort or mild swelling, occasional headache, or mild fatigue, particularly with appropriate dosing and patient preparation including adequate hydration