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In the brain, they are most highly expressed in the hypothalamus, specifically the ventromedial nucleus and arcuate nucleus
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have demonstrated that overactivation of the Hedgehog signaling pathway in the ovary inhibits ovulation
A woman starting at 190 lb who loses 24% drops about 46 lb
In ovariectomized mice (an animal model for menopause), estrogen replacement increased GLP-1 secretion from both intestinal L-cells and pancreatic alpha-cells
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