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The gene expression PCA plot confirmed transcriptomic-wide differences between GSH-sufficient Gclc fl/fl MZB and Gclc fl/fl FoB (Fig
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When in the reduced state, GSH is active and protects cells and DNA by neutralizing reactive oxygen species, such as naturally occurring peroxides and free radicals produced during metabolism that could otherwise damage cellular components
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Taken together, these findings suggest that alleviation of the weight loss and inflammatory exacerbation associated with UC resulted in a significant decline in mortality in the Si-DSS group compared with that in the Con-DSS group (Table 1)
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