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Some metabolic effects may begin earlier, but the most meaningful weight loss results in trials developed over several months , especially as participants progressed through dose escalation and reached higher maintenance doses
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The patients who do best usually treat this period as active medical follow-up, not a passive prescription refill
A meta-analysis of 40 preclinical studies involving 992 diabetic rodent models demonstrated that MSC-based therapies markedly improved renal function and attenuated key pathological features, including fibrosis, inflammation, apoptosis, and oxidative stress (251)
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