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Topical bixin confers NRF2-dependent protection against photodamage and hair graying in mouse skin

Unlike intramuscular delivery, theres essentially no risk of nerve injury

upregulation of antioxidant enzymes like catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GR) glutathione peroxidase (GPx), heme oxygenase, endothelial nitric oxide synthase, and other protective proteins (5)

Uddandrao VVS, Parim B, Singaravel S, Ponnusamy P, Ponnusamy C, Sasikumar V, et al

Inspect each vial for cracks, damaged seals, or signs of contamination

Significant weight loss is typically observed within 2-6 months of consistent use, alongside a healthy diet and regular exercise