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Keaveney 2020)
Numerous studies had demonstrated that APX3330 specifically inhibited APE1 REDOX signaling in a variety of tumor models in vitro and in vivo, including pancreatic cancer, leukemia, and malignant peripheral nerve sheath tumors (MPNSTs) [28]
Most of the copper in the liver is excreted in the bile, but less than 5% of the copper circulates in blood serum bound to ceruloplasmin and also as unbound free serum copper
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