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Saxenda (approved 2014, titrated to 3 mg) was the first GLP-1 approved specifically for weight management and is licensed for adults and adolescents aged 12 and up

Serum liver fatty acid binding protein shows good correlation with liver histology in NASH

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Increased postprandial GLP-1 levels observed predominantly in male Tmprss2 / mice indicated an additional sex-specific mechanism unrelated to the activation of PAR2 by TMPRSS2

The 503A pathway for patient-specific compounding by state-licensed pharmacies remains available under a narrower framework, requiring that the prescriber document a "significant difference" justifying why the compounded version meets the specific patient's medical need in a way the FDA-approved product cannot

And as for those drugs, they really work, he says