However, in glutathione synthetase deficiency, because the activity of gamma-glutamyl-cysteine synthetase is regulated via feedback inhibition by glutathione, gamma-glutamyl-cysteine and then L-5-oxoproline are overproduced, resulting in the metabolic acidosis and urinary excretion of this compound at levels several hundred-fold above normal (71
Grains and some nuts contain selenium when grown in selenium-containing soils
For the complex structural model of FOXO4-DRI and p53 TAD2 we generated 1000 structural models of FOXO4-DRI bound to p53 TAD2
Physical causes include nerve damage, hormonal issues, and medication side effects, particularly from certain antidepressants
One domain facilitates the ATP-grasp mechanism [8] and the other is the catalytic active site for -glutamylcysteine
Scott BL, Lee CS, Shi LL, Lee MJ, Athiviraham A