In HG-induced HK-2 cells, mitoQ maintained mitophagy by restoring Nrf2 expression and activity, as well as the PINK and Parkin expression to reduce cell injury (68)
It also modulates NF-kB, one of the primary inflammatory signaling pathways involved in chronic low-grade inflammation
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Krebs LT, Kramar EA, Hanesworth JM, Sardinia MF, Ball AE, et al