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(A) Longitudinal melanonychia in a child
For weight management, the FDA-approved options are Wegovy (semaglutide), Zepbound (tirzepatide), and Foundayo (orforglipron)
I tracked down the doctor they quoted
doi: 10.1111/dom.14255, 54 GrahamD
The contributions of GIP and glucagon receptor activation to bowel changes are not yet well characterised for retatrutide specifically, and any claims about their effects on gut motility or intestinal secretion remain uncertain given the medicine's investigational status
Orforglipron sidesteps the problem altogether
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