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The molecular mechanisms underlying CVD have been extensively investigated over the past decades

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Combination therapy with canagliflozin plus liraglutide exerts additive effect on weight loss, but not on HbA1c, in patients with type 2 diabetes

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The disease affects children as young as two years old

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Participants also recorded reductions in waist circumference (average 7.1cm loss on 6mg, 8.2cm on 12mg, 10cm on 36mg, compared with 3.1cm loss on placebo), blood pressure (estimated -4.2 and -1mm HG difference between placebo and orforglipron in systolic and diatolic blood pressure, respectively) and cholesterol (-2.1% difference between placebo and orforglipron)

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Symptoms may include: Mild, sporadic back pain Mild leg fatigue after long periods of standing and walking Mild back stiffness Stage 2 (Moderate Stenosis): Symptoms Become More Disruptive Stage 2 stenosis shows a moderately obliterated anterior CSF space, with some cauda equina that cant be visually separated

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