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Studies in obese rats have reported increased iron and hepcidin levels, as well as defects in mitochondria and endoplasmic reticula in the testis, which have been shown to be involved in ferroptosis [109]

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If necessary, patients may transition to a more potent medication or explore whether surgical options could provide longer-term stability

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PICO, PICOS and SPIDER: a comparison study of specificity and sensitivity in three search tools for qualitative systematic reviews