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It remains to be delineated how GLP-1R may modulate ICP directly and indirectly, whether it compromises the blood-CSF barrier or affects CSF reabsorption, if species-specific differences may occur, and if off-target effects may contribute to modulation of the CSF dynamics

To check whether these SNPs are associated with CVD or its risk factors via other phenotypes rather than via l-carnitine, we also assessed the association of these selected SNPs with potential causal factors for CVD, including Townsend index, education, smoking, and alcohol drinking in the UK Biobank, which are well-known factors affecting CVD and possibly l-carnitine