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The condition must be confirmed by genetic testing demonstrating variants in POMC, PCSK1, or LEPR genes that are interpreted as pathogenic, likely pathogenic, or of a variant of uncertain significance (VUS)

Hao et al

Elevated levels of homocysteine, an amino acid that inflicts damage to the inner arterial lining and contributes to many diseases, including Parkinsons, can be lowered through supplementation with Vitamins B6, B12 and B9

Conclusions GLP-1RAs are effective in reducing body weight, BMI, and insulin resistance in patients with PCOS, particularly those with obesity or metabolic complications

The concern is pharmacodynamic and indirect

Sperm is especially prone to damage from reactive oxygen species (ROS)