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The rest rely on preclinical data alone

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As indicated by research in monkeys, Epithalon restores melatonin production to normal rates

56 PrkacinI.SeparovicJ.AraliciaG.PerovicD.GjurasinM.Lovric-BencicM.et al (2001)

8, 9, 10 The perception that a breach in the mucosal barrier incites mucosal inflammation is supported by the physical location of the intestinal epithelium, interposed as it is between the luminal contents and the mucosal surface (Figure 1)

The side effect profile becomes more significant at this level, and careful monitoring is important