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The distribution of these isoenzymes varies across the body, PDE1A and PDE1B are highly expressed within the brain, while PDE1C is found within the lungs, heart, and bladder (Lakics et al., 2010)

When comparing the responders from the CRWP group ( n = 12) to the non-responders in the same group ( n = 7), there was a significant difference in age with the responders being significantly older (4.23 0.22 years) than non-responders (3.48 0.18 years

"Exosome-based therapeutics for fibromyalgia: Targeting neuroinflammation and pain pathways." Pain Medicine , 25(3), 201-217

Nature 599 , 136140 (2021)

Groups 2 and 3: rats were fed on basal diet and drinking color mix fruit juice for 6 and 12 hours