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2 Structure and Physiology of Glucagon-Like Peptide-1 (GLP-1) The incretin hormone GLP-1 is derived from the processing of proglucagon that occurs in ileal L cells and the nucleus tractus solitarius (NTS) [11]

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After GLP-1 binding, G protein conjugates GLP-1R receptors to activate adenylate cyclase (AC) and increase intracellular cAMP levels