162 A trial in 17 healthy female nurses working rotating or night shifts found drinking 333 mL (about 12 ounces) of a hoppy non-alcoholic beer nightly for two weeks resulted in shorter time to fall asleep and better sleep quality as assessed by actigraphy
Below 0.1 indicates significant suppression that requires prompt dose reduction
Obsessive-compulsive disorder (OCD): An RCT in 48 patients found that NAC (2,400 mg/day) as an add-on to fluvoxamine significantly improved Yale-Brown OCD Scale scores compared to placebo over 12 weeks (Afshar et al., J Clin Psychopharmacol, 2012) [72]
As always, treatment decisions should be individualized, considering kidney function, comorbidities, adverse-event profile, costs and reimbursement, and patient preferences
Tirzepatide is also a once-weekly injectable, but it works on both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors
However, this effect is soon weakened, not affecting the normal heart rate (108)