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Pregnancy considerations: Tirzepatide is not recommended during pregnancy, and women of childbearing potential should be advised that tirzepatide may reduce the effectiveness of oral contraceptives, particularly during initiation and dose escalation
Chen J, Huang Z, Chen Y, Tian H, Chai P, Shen Y, et al
Wnt/-catenin signaling promotes DE specification by induction of NODAL gene expression (Wild et al., 2020)
This efficacy limitation, rather than safety concerns, halted further development
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