Early data showed promising efficacy in non-diabetic obese patients comparable to Lillys Orforglipron with a downward trend in weight loss, although the effect size was less than that of Orforglipron in diabetes subgroup
However, some women do not ovulate despite receiving increasing doses of clomiphene citrate, and are therefore considered to be clomiphene citrate-resistant
These trials tested the preventive effects of samidorphan, enrolling only non-obese patients (mean BMI 25.7)
What are the side effects of retatrutide
We also examined the three-year prevalence of angina, transient ischemic attack (TIA), myocardial infarction (MI), ischemic stroke, and hemorrhagic stroke among 208,692 patients on any dose of a GLP-1 medication and 208,388 patients who had bariatric surgery
The TRIUMPH-1 trial (Jastreboff et al., NEJM 2023) documented 24.2% weight loss at 48 weeks at the 12 mg dose unprecedented for an incretin mimetic