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Long-term use may be needed for lasting relief

So far, clinical trials havent resulted in regulatory approval, and pharmaceutical companies havent been motivated to invest in further development

Proposed Mechanisms (Preclinical) FOXO4p53 Axis in Senescent Cells Based on work showing FOXO4 association with p53 in senescent cells

However, Compound 12 was unfortunately identified as a substrate of multidrug resistance protein 1 (MDR1, P-gp) in MadinDarby canine kidney (MDCK) cells with an efflux ratio greater than 5, which precluded its development as a candidate for CNS drugs

The body's ability to respond and repair slows down

(January 2014)