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In experimental models, this pulsatile GH elevation activates hormone-sensitive lipase and promotes lipolysis specifically in deep abdominal fat depots

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Dose for maintenance: 1

It also exerts beneficial effects on an essential bacterium for the health of the intestinal lining, Akkermansia muciniphila

It produced slightly better A1c reduction than Byetta BID in head-to-head trials and with less frequent nausea after initial weeks ( [61] ) ( [101] )

The trial in people with T2D included 281 participants (mean age 56 years, 56% women, mean BMI 35.0 kg/m 2 , mean HbA1c 8.3%) treated with lifestyle only and/or metformin, with similar intervention arms to the obesity trial, albeit retatrutide 0.5 mg rather than 1 mg, and dulaglutide 1.5 mg was an additional comparator [46]