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Although culture methods allow for the isolation of live strains, they have low sensitivity and require long incubation times
However, its application in the context of neurodegenerative disorders may be limited by some contrasting or inconclusive results, representing a constantly evolving area of research
For FGF21 analogs, this is likely to require balanced agonism of FGFR1c, FGFR2c and possibly FGFR3c
Selvarathinam et al
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