Presented for research literature review only Sima AA (2007)
Discussion In this paper, we develop the first mathematical model of the GSH antioxidant system in the outer retina, capturing the most essential components for ROS creation, GSH production, oxidation in neutralizing ROS, and reduction as well as the diversion of glucose into the PPP to synthesize NADPH
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In addition, studies have found that TMAO increases NADPH oxidase activity, induces the production of ROS, and an increase in ROS can promote the translocation of NF-B from the cytoplasm to the nucleus (68)
Semenkovich K, Brown ME, Svrakic DM, Lustman PJ
Carnitine levels decrease with age [151]