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G.SiljeholmC.Di IorioA.De AmicisD.SaliniV.et al (2009)

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The multitude of positive feedback loops suggests that treatment strategies with a single drug acting on a single therapeutic pathway or transcription factor have little chance of bringing the patient out of hyperinflammatory or chronic state, as the remaining active positive feedback loops continue to drive inflammation and oxidative stress, leading all the time, but only slightly weaker, to the destruction of the system