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Myelin breakdown and iron changes in Huntingtons disease: pathogenesis and treatment implications

10.1016/j.intimp.2022.108553 26 FarzanM.FarzanM.ShahraniM.NavabiS

So if you took B12 and felt worse, and your blood B12 is elevated, and you have a constellation of symptoms across multiple systems that's three signals pointing toward MCAS as worth ruling out

These proteins play significant roles in biological quality control, programmed cell death, hemostasis and catabolic processes, protein folding, cellular oxidant detoxification, coagulation, and retinal homeostasis

10.3389/fimmu.2013.00480 239 RyanS

A blood test tells you that, so you are treating a real, measured problem rather than guessing