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These drugs were promising early on, but many were abandoned for either failing to show clear benefits or for allegedly causing severe side effects

Elevated levels of IL1A , IL1B , and IL1RN were observed in MAC.2 and Inf.MAC cells in TCMR, while significant IL1RL1 elevation was noted exclusively in migDCs in ABMR, suggesting a mixed inflammatory pattern of IL-1 cytokines in rejection samples ( Figure 5F )

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To determine whether these transcriptomic changes were reflected at the metabolic level, we quantified -hydroxybutyrate, a terminal product of -oxidation, in both cell lysates and culture supernatants

Reichheld, J

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