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established a two-stage chemical cocktail to directly reprogram MEFs to iHeps (Yang et al., 2020)
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Earlier oral trial METAOD005 randomized 300 adults with obesity to oral AOD-9604 (1, 5, 10, 20, or 30 mg/day) or placebo for 12 weeks
Reconstituted peptide solution should be stored around 4 degrees Celsius but not frozen, while lyophilized peptide solution should be kept at -20 degrees Celsius AOD9604 is sold for laboratory research use only
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