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Beharry KD, Valencia GB, Lazzaro DR, Aranda JV (2016) Pharmacologic interventions for the prevention and treatment of retinopathy of prematurity
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While nutritional VC intake demonstrates chemopreventive effects by scavenging carcinogen-induced reactive oxygen species (ROS) and maintaining genomic stability, high-dose intravenous VC acts as a prooxidant to selectively kill tumor cells via ROS-mediated deoxyribonucleic acid (DNA) damage, adenosine triphosphate (ATP) depletion, and HIF-1 degradation
Nutr Cancer 1996
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