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395 Intriguingly, even in instances where allopurinol is not adjusted according to the estimated glomerular filtration rate (eGFR), approximately one-third of patients fail to attain SU levels below the designated threshold of 6.0 mg/dL

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As the liver serves as a central hub for amino acid synthesis, degradation, and interconversion, perturbations in systemic amino acid profiles are frequently observed in hepatic dysfunction (74)

Consequently, this study utilized the DSS-induced UC model to investigate the therapeutic efficacy and mechanisms of action of GHK-Cu