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Medicare currently covers GLP-1s for diabetes, sleep apnea, cardiovascular risk reduction, and MASH

Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term studies in animals to evaluate carcinogenic potential have not been done

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Patient satisfaction was low relative to objective improvement

Cell-culture research has shown that reducing NNMT was associated with less lipid accumulation in fat cells, while increasing NNMT was associated with more suggesting NNMT contributes to adipocyte function rather than simply marking metabolic dysfunction

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