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Potential side effects may include injection site irritation, water retention, appetite changes, headaches, fatigue, dizziness, blood sugar changes, nausea, hormone imbalance, drug interactions, or unknown long-term effects

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Common side effects include: Nausea (especially when first starting the medication or increasing the dose) Vomiting Diarrhea or constipation Stomach pain or cramping Fatigue Acid reflux or heartburn Doctors usually start patients on a very low dose and gradually increase it over several months

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Moreover, GLP-1RAs can suppress atherosclerosis in T2DM (STZ treated) rats by inhibiting macrophage infiltration and apoptosis [66]