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Exploring GLP-1 Agonists GLP-1 agonists are medications originally developed for diabetes management, which have shown effectiveness in aiding weight loss

They also improve some symptoms in patients with anxiety disorders, depression, Obsessive-Compulsive Disorder (OCD), Post-Traumatic Stress Disorder (PTSD), and social anxiety disorder

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The most comprehensive evidence comes from three sources: the Phase 2 trial published in the New England Journal of Medicine , the Phase 3 TRIUMPH-4 trial, and a systematic review and meta-analysis that synthesized data from 878 total participants across three randomized controlled trials

Call 911 or seek immediate medical attention if you experience: Black, tarry stools or blood in vomit (coffee-ground appearance), which may indicate gastrointestinal bleeding Severe or persistent abdominal pain that differs from typical semaglutide-related discomfort Sudden onset of chest pain, shortness of breath, or symptoms of heart attack or stroke Signs of allergic reaction, including rash, swelling, or difficulty breathing Decreased urine output, swelling in the legs or feet, or other signs of kidney problems Semaglutide can rarely cause pancreatitis

And we saw there were cases where evidence had flip flopped based on larger and better studies that have come out