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In Cleveland Clinic's 2025 analysis of real-world use, semaglutide 2.4 mg produced mean weight loss of approximately 14.1% at one year versus the ~15% trial number, and tirzepatide produced approximately 16.5% versus the 22% trial number
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A randomized trial assessing the effect of tirzepatide (Mounjaro/Zepbound) found that withdrawing tirzepatide led to substantial regain of lost weight in less than two years
This ensures a personalized approach to treatment from the outset
Dehydration cuts that flow
