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When SILY was co-administered with SERT, we observed significant improvements in the oxidant antioxidant balance, and an antiinflammatory response over the effects observed with SERT alone, also reinforcing our opinion that SILY when examined in a rodent model of depression exhibited both adjunctive and sole therapeutic benefits

Rodent toxicity studies from the Sikiric group have not identified significant acute toxicity

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In summary, ferroptosis is intimately linked to the initiation and progression of AD, PD, MS, and ALS, as evidenced by strong concordance between findings from clinical human samples and those derived from animal and in vitro models