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F1000Res (2020) 9:F1000 Faculty Rev-239

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This ubiquitous protease is expressed in several tissues, including pancreatic -cells, and cleaves the amino-terminal dipeptide at the penultimate position with either L-proline or L-alanine (GLP-1), limiting the clinical utility of GLP-1 in T2DM patients, particularly its insulinotropic actions (Saini et al., 2023)

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