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Main cause: Slower gut movement can dry and delay stool

Patients taking insulin or sulfonylureas should monitor their blood glucose more frequently when reducing meal sizes, as the risk of hypoglycaemia may increase

Heart Failure * Initial dose: 2.55 mg once daily

The trial used a three-week dose-escalation schedule, raising the daily amount in steps to the full 500 mg, which the authors used to limit early gut symptoms [4]

As with any new supplement, it is always a good idea to consult with your healthcare provider, especially if you are taking medication.

Mild nausea is common and typically resolves within three to five days of the increase