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"I'd say maybe only a handful of people at most in the last 10 years have I ever actually thought would benefit from B12 injections." As to why some physicians would be needlessly prescribing B12 shots, he said, "It may be just habit
The average is around 2 to 5kg over the transition years
For example, patients with a history of Medullary Thyroid Cancer are not appropriate candidates for these treatments
Over time, pharmacological engineering enabled: Short-acting injectables (e.g., exenatide) Long-acting once-weekly injectables (liraglutide, semaglutide) Multi-target incretin therapies (tirzepatide) Oral peptide formulations and now oral small molecules The most recent breakthrough is the development of orally available GLP-1 receptor agonists, including: Orforglipron (Lilly) Elecoglipron (AstraZeneca) These compounds eliminate the need for injection and could dramatically expand accessibility and adherence in obesity and diabetes populations
Which b12 is better methylcobalamin or cyanocobalamin
No published head-to-head study exists
