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GLP-1 receptor agonists bind to GLP-1 receptors in the pancreas, stimulating insulin secretion in a glucose-dependent manner whilst suppressing glucagon release

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31 Oral semaglutide Challenges regarding the development of oral GLP-1 RA The major barriers preventing the oral administration of a peptide or protein drug are presented by the enzyme-mediated peptide degradation and ensuing hydrolysis, the low permeability of intestinal epithelium and its mucus layer, and the pH differences between the acidic stomach and the basic intestinal lumen