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Pharmacokinetic and endpoint data from human studies does not transfer to an in vitro system or to a rodent model, and the receptor-level measurements that do transfer are a small fraction of the total citation volume

Some individuals report mild gastrointestinal upset

Serious adverse events occurred in 3-7% of active-treatment arms and 2% of the placebo group

546,547 Olpasiran demonstrated a dose-dependent reduction in Lp(a) levels, with a single dose of 9 mg or higher reducing Lp(a) concentrations by over 90% for several months (NCT03626662)

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